The massacre was reported at 5 a.m. on Sunday, the Quintana Roo Attorney General's Office said.
Gunmen attacked the house in one of the poorest neighborhoods in Cancun with a range of firearms, Efe news reported.
A manhunt has been launched, the police said adding that it could be a drug traffickers dispute.
They blamed the violence on a turf war involving the Jalisco Nueva Generacion Cartel, the Los Zetas cartel and other gangs that want to control the illegal drug trade in the region.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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