The incident took place on Thursday on Interstate 75 near Gainesville, said Alachua County Fire Rescue on the social media.
The Florida Highway Patrol said the crash involved two tractor trailers, a sedan and a passenger van. All vehicles but the sedan caught fire, Xinhua news agency reported.
Alachua County Fire Rescue said the fire, fed by about 190 liters of diesel, was later extinguished.
Emergency crews said they were treating the crash as a homicide investigation.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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