The two-time Wimbledon champion took an hour and 50 minutes to eliminate Sela, world No. 127, moving a step closer to claiming his 18th Grand Slam title, reported Efe.
Nadal broke Sela's serve six times and struck 31 winners compared to his Israeli opponent's 18.
Nadal was starting at Wimbledon without having played a competitive grass-court match this season, after pulling out of the Queen's Cup tournament to regroup after an outstanding string of clay-court victories, including his 11th Monte-Carlo Masters, Barcelona Open and French Open titles.
In the next round, the 32-year-old Spaniard will play the winner of the match between Canada's Vasek Pospisil and Russia's Mikhail Kukushkin.
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