The crash occurred on a bridge as the tanker headed out of Lagos, toward the 127.6 km Lagos-Ibadan expressway in Nigeria's southwest region, Xinhua reported.
The local Channels Television reported that traffic has been stopped on both sides of the road and emergency officials are at the scene trying to put out the fire and attend to those affected.
Many people were seen trapped in their cars amid the raging fire, eyewitnesses said.
There was a mild traffic on the bridge when the explosion occurred, said Gbolahan Adebisi, a commercial bus driver who witnessed the incident.
Local emergency officials said about 60 vehicles were seen to have been affected by the fire so far.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
