The 25-year-old Real Madrid player is to replace goalkeeper Hugo Lloris, who will not start in Tuesday's game, reports Efe.
"It is a sign the coach (Didier Deschamps) is confident in me. It is a responsibility that I have already taken other times with the same pride," Varane said during a press conference.
France currently leads Group C with six points after beating Australia 2-1 and Peru 1-0, while Denmark holds the second spot with four points.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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