President Miguel Diaz-Canel said many are feared dead, according to Sky News.
The plane came down shortly after take-off and exploded on the "highway" between Boyeros and Havana, near the Jose Marti International Airport here, Radio Habana Cuba tweeted.
Fire crews and ambulances were at the scene, BBC reported.
The plane reportedly belongs to Cubana de Aviacion. The flight was headed to Guyana, an airport source told CNN.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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