The 33-year-old Iniesta came through the ranks and has been playing with Barcelona since 1996, a 22-year career that has seen him become one of Spain's most legendary midfielders, reported Efe.
"Out on the field at Camp Nou Andres, Iniesta could make his final appearance in a Clasico after 37 previous appearances in the fixture, 25 of which have come in La Liga," the club said in a statement on its website.
Barcelona is to face off against its main rival Real Madrid on Sunday.
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