Australian Behrendorff is suffering from a back problem and has been ruled out of the Twenty20 cricket tournament, according to a statement.
"In accordance with the Player Regulations, the Mumbai Indians were allowed to choose a replacement from the Registered and Available Player Pool (RAPP)," IPL said after the tournament's Technical Committee approved the replacement.
Three-time IPL champions Mumbai Indians picked left-arm pacer McClenaghan at his base price of Rs 1 crore.
The 31-year-old was part of Mumbai Indians squads which won in 2013, 2015 and 2017.
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