Jaime Valdez converted a spot-kick in the 73rd minute for the Santiago club at the Ester Roa stadium in the southern city of Concepcion on Saturday, reports Xinhua news agency.
Uruguayan striker Octavio Rivero doubled the visitors' lead before forward Nicolas Orellana blasted a shot past Bolivian goalkeeper Carlos Lampe.
With the victory, Colo-Colo finished two points above rivals Union Espanol in the competition standings.
Universidad Chile were third, a point further back.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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