Real Madrid right-back Dani Carvajal, FC Barcelona veteran midfielder Andres Iniesta and Chelsea striker Alvaro Morata have all had to withdraw from the 25-man squad due to physical issues, reports Xinhua news agency.
The three injured stars have been replaced by defender Alvaro Odriozola, midfielder Jonathan Viera and forward Aritz Aduriz. They will train on Monday under Lopetegui.
Morata pulled a hamstring during Chelsea's 0-1 defeat to Manchester City. Iniesta also suffered a hamstring strain as Barcelona defeated Las Palmas on Sunday.
Carvajal missed Sunday's game at home to Espanyol with pericarditis, which is an inflammation surrounding the heart, and will be out of action for an as-yet-unspecified length of time.
Spain are set to host Albania on Friday, while the squad will travel to Jerusalem to face Israel on October 9.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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