Midfielder Nikao on Wednesday opened the scoring for Atletico before goals to Kayke and Bruno Henrique gave the visitors a 2-1 lead.
Kayke netted again just after the hour mark and then Ederson pulled a late goal back for the hosts.
The return leg will be played at Santos' Vila Belmiro stadium on August 10.
In other matches on Wednesday, Ecuador's Barcelona de Guayaquil won 1-0 at home to Palmeiras of Brazil and Bolivia's Jorge Wilstermann secured a 1-0 home victory over Brazilian club Atletico Mineiro.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
Doraiah Chowdary Vundavally is a Software engineer at VTech . He is the news editor of SocialNews.XYZ and Freelance writer-contributes Telugu and English Columns on Films, Politics, and Gossips. He is the primary contributor for South Cinema Section of SocialNews.XYZ. His mission is to help to develop SocialNews.XYZ into a News website that has no bias or judgement towards any.
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