Sevilla FC's poor run into the international break has left the title to once again be fought out between Spain's two biggest clubs with Real Madrid holding the advantage over Barca.
Real Madrid are currently on 65 points, two ahead of Barcelona. They also have a game in hand, reports Xinhua news agency.
Sunday will see them look to extend that lead against Deportivo Alaves, whose results have taken the side from Vitoria to the verge of the battle for Europe, just four points off seventh place, which would give them a ticket for next season's Europa League.
The Basques will be without a key player on Sunday however, as influential midfielder Marcos Llorente is not allowed to play against Madrid due to a clause in the loan deal with his parent club.
Real Madrid should be at full strength with the only debate over whether or not Keylor Navas continues in goal or if Kiko Casilla could be given a chance.
It is a busy week for sides in Spain, but Madrid have the advantage that none of their matches take them away from the capital.
Barcelona meanwhile are return with one of their longest trips of the season as they visit second from bottom Granada, who have just 19 points and four wins all season.
Lionel Messi is a big absentee for Barcelona as he misses out due to suspension after completing a cycle of bookings in the last game before the international break.
Messi's absence will place extra pressure on Neymar and Luis Suarez and Barca coach, Luis Enrique will hope they have recovered from their transatlantic flights to represent their respective countries.
Barcelona will know Madrid's result by the time they kick off, but whether or not that is an advantage or added pressure is a moot point, given that whatever happens they cannot afford to drop points against a rival that looks condemned to the drop.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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