Vincent de Rivaz on Saturday pointed to the risks caused by some critics "losing sight of the bigger picture by overlooking the positive impact and importance of this investment for Britain", Xinhua news agency reported.
One month ago, May ordered a review of the 18 billion British pound ($23.6 billion) Hinkley Point C project, which will be built and mainly funded by the EDF. China also agreed to take a third of the investment.
De Rivaz said the project brings the benefits of a 30-year partnership between the EDF and its nuclear construction partner in China, a country with the largest civil nuclear programme in the world.
"We know and trust our Chinese partners. Beyond that, British independent nuclear regulator has only granted Hinkley Point a nuclear site license after being satisfied that security has been properly addressed," the EDF chief said.
According to De Rivaz, all staff of nuclear projects are rigorously vetted. As is standard practice, the control systems at Hinkley Point C will be isolated from IT systems and the internet, he said.
"The cost of Hinkley Point C's electricity is frequently compared with today's depressed wholesale prices. The correct comparison is with future prices. Hinkley Point C is competitive with all other future energy options, even including fossil fuels like gas when the cost of carbon is taken into account," he added.
De Rivaz said that neither battery storage nor small modular reactors are viable or competitive as compared with the nuclear technology applied the Hinkley project which will alone supply seven per cent of Britain's electricity demand.
Hinkley Point will benefit the British economy by creating thousands of jobs and hundreds of apprenticeships and billions of pounds will be invested into the economy of England, said the EDF chief.
"Across Britain, dozens of companies and our own workforce are ready to deliver this project. Their motivation remains high and they are looking forward to getting on with the job," he said.
