The accused, Rahim Daad, is believed to have murdered his first wife over the same reason some 14 years ago, police said.
On Wednesday night, the newspaper said, the couple had a minor scuffle after which the woman, 35, tried to flee from their Karachi house.
She told him that she didn't want to stay with him any longer. He took out a knife and attacked her, a police officer said.
"He stabbed her in the abdomen and then slit her throat," a police official told the Dawn, adding the murder was committed on the pretext of the "honour of his family".
Their landlord alerted the police after he heard her cries from their groundfloor apartment. Police have recovered the knife from the murder spot and Daad has confessed to have committed the crime.
