Police said the teenager was declared dead shortly after he was rushed to Westmead Hospital, EFE news reported.
Of the six wounded, a 21-year-old man was in critical condition, while the others were discharged.
According to several media outlets, the police received a call from a house in Sydney's Ryde suburb just after midnight, following a brawl among several young men at the party.
The police said the case was being treated as a homicide.
"This is a very, very serious matter and we hope to get to the bottom of it," he said, adding that investigators were waiting to speak to those present at the party.
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