The 225-issue Nikkei Stock Average lost 89.14 points, or 0.53 per cent, from Wednesday to 16,575.68, Xinhua news agency reported.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange dropped 9.20 points, or 0.70 per cent, to 1,312.47.
Decliners were led by air transportation, banking and insurance issues.
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